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triclosan
many of you have seen consumer product labels w/ the product 'triclosan' as
a disinfectant or antimicrobial (especially now that epa has laxened its
allowe-without-having-to-register-as-a-pesticide pesticidal claims policy).
i had been assuming it may be a chlorophenol, contaminated w/ dioxins et
al., because of the name & because it many past (and current?) consumer
products, incl. toothpaste & mouthwasah & soaps, contain chlorophenols.
there was recently some mass media reporting of a newly fda aproved colgate
toothpaste, with triclosan, that fights gingivitis & plaque. i finally
overcame my inertia, and after several tries learned from fda the c.a.s.
no. what follows is the various files i was able to download from the web
using the cas # (no tox. factsheets--i didn't check the pesticide tox
factsheet sites, and the ntp's site (the best, least biased ones) was
down).
shock & horror, i saw triclosan (which is a chlorophenol after all) has the
following structure (pardon the crummy representation):
OH Cl
\/\ _O_ /\/
| | | |
Cl/ \ / \/ \Cl
yet again, all but a dioxin, thus likely to be heavily contaminated w/ same...
note one of its synnonyms, containing "2,4-dichlorophenoxy", tho i can't
quite see the familiar, one ring, 2,4-dichlorophenoxy herbicide
structure...
anyone w/ something to add about the prevalence of such compounds in
consumer products we ingest or apoply to skin, about levels of pcdd/f/hcb
etc contamination, past or present, please post to the list. i for one
would love to learn more, and i never cease to be stunned by the toxins we
allow in our consumer products. it's as if we were back in the 1940's and
'50's...
---------
Triclosan (Irgasan DP 300)
Formula
MI Number
CAS Number
C.I.Number
C12H7Cl3O2
9573
3380-34-5
MI: Merck Index Number
CAS: Chemical Abstract Service Registry Number
C.I.: Chemical Index Number
Background
Triclosan (Irgasan DP 300) is a diphenyl ether used as a preservative and
disinfectant. Irgasan DP 300 incorporated into such footwear as men's
hosiery and insoles of shoes are called "odor-eaters" because it is claimed
that this chemical can suppress the odor produced by foot organism.
Synonyms
2,4,4'-Trichloro-2'-hydroxydiphenyl ether
5-Chloro-2-(2,4-dichlorophenoxy) phenol
CH 3635
Irgasan Ch 3635
Irgasan DP 300
Ster-Zac
Triclosan
Uses
Anti-odor insoles and hose
Bath additives
Commercial laundry products
Cosmetics
Deodorant soaps
Deodorants and antiperspirants
Detergents
Disposable paper products
Foot powders and sprays
Laundry products
Shampoos
Textile treatment
Cross-Reactions
Unusual Reactions
References
1. Maurer, T., et al., Predictive evaluation in animals of the contact
allergenic potential of medically important substances. II. Comparison of
different methods of cutaneous sensitization with "weak" allergens.
Contact Dermatitis, 1979. 5(1): p. 1-10.
2. Veronesi, S., et al., Contact dermatitis to triclosan. Contact Dermatitis,
1986. 15(4): p. 257-8.
3. Zaugg, T. and T. Hunziker, Germall II and triclosan [letter]. Contact
Dermatitis, 1987. 17(4): p. 262.
4. Steinkjer, B. and L.R. Braathen, Contact dermatitis from triclosan
(Irgasan DP 300). Contact Dermatitis, 1988. 18(4): p. 243-4.
5. Perrenoud, D., et al., Frequency of sensitization to 13 common
preservatives in Switzerland. Swiss Contact Dermatitis Research Group.
Contact Dermatitis, 1994. 30(5): p. 276-9.
[this one's from calif's pesticide regulation branch, i clicked for the
company reports, but they never showed up]
Output Reporting
Query Parameters
PC Code(s): 054901
79 labels match.
Select a sort method
Scroll down and put a check by all the products you would like more details
on.
Then press the Report button:
1624-108() 20 MULE POWER BATHROOM CLEANER
1624-109() 20 MULE POWER BATHROOM CLEANER
1624-110() 20 MULE POWER BATHROOM CLEANER
57125-8(Active) 20 MULE POWER BATHROOM CLEANER
57125-7(Active) 20 MULE POWER SPRAY BATHROOM CLEANER
6718-19(Cancelled) AMWAY DETER SHOE AND SOCK SPRAY
1913-23(Cancelled) AUTOMATIC VANISH TOILET BOWL CLEANER
42964-9(Active) BAC - TEX
100-491(Cancelled) BACTERIOSTAT CH 3565
8238-4(Cancelled) BARRIER DET BACTERIOSTAT SUPER CONC FED SPEC
P=001397 (GSA-FSS)
7048-11(Active) BIO-MAGIC RINSE G
7048-9(Cancelled) BIO-MAGIC RINSE G LIQUID
7048-10(Cancelled) BIO-MAGIC RINSE G-100
70648-1(Active) BIOKRYL I
475-187(Cancelled) BLUE AUTO SANIFLUSH TOILET CLEANER &
DEODORIZER FORMULA A
475-178(Cancelled) BLUE SOLID SANI FLUSH TOILET CLEANER AND
DEODORIZER
57125-6(Active) BORAXO DISINFECTANT TILE, PORCELAIN, &
FIBERGLASS CLEANER
3573-33(Cancelled) CONCLUDE G POWERED BACTERIOSTATIC FABRIC
SOFTNER
8238-5(Cancelled) CONQUEST DETERGENT-BACTERIOSTAT SUPER
CONCENTRATE FED. SPEC. P-D-00139
8238-7(Cancelled) DETER-BACTERIOSTAT #306 SUPER CONC- FEDERAL
SPEC P-D001397 GSA-FSS
8238-6(Cancelled) DETERGENT-BACTERIOSTAT #304 SUPER CONC FED
P-D 001397 (GSA-FSS)
70413-1(Active) GERM-STAT 1
100-502(Active) IRGASAN DP 300
875-110(Active) ISSUE PLUS II
1677-37(Cancelled) LAUNDRI SOFT
1677-110(Cancelled) LEMON SOFT PLUS
6142-20() LEMON SOFT PLUS
42182-1(Active) MICROBAN PLASTIC ADDITIVE "B"
9647-17(Cancelled) MYCO 30 DUST MOP
9647-16(Cancelled) MYCO S-45 BACTERIOSTATIC DUST CONTROL AGENT
475-171(Cancelled) NEW SANI-FLUSH TOILET CLEANER & DEODORIZER
11525-7(Cancelled) P/P DISINFECTANT CLEANER NO. 1
499-338(Cancelled) P/P OUTDOOR LOTION
499-340(Cancelled) P/P OUTDOOR LOTION
11525-12() P/P OUTDOOR LOTION
11525-22() P/P OUTDOOR LOTION
335-214(Cancelled) PENBRITE-S
1677-161(Cancelled) PENNSTAT
67303-2() PENNSTAT
1677-160(Cancelled) POWDERED PENNSOFT G BACTERIOSTATIC FABRIC
CONDITIONER/LEXOL 300
67303-1() POWDERED PENNSOFT G BACTERIOSTATIC FABRIC
CONDITIONER/LEXOL 300
3090-170(Cancelled) SANITIZED BRAND BACTERIOSTATIC ADDITIVE
WWD-2
3090-174(Cancelled) SANITIZED BRAND BACTERIOSTATIC CHEMICALS
SLC FOR INDUSTRIAL USE ONLY
3090-173(Cancelled) SANITIZED BRAND BACTERIOSTATIC FABRIC
SOFTENER
3090-199(Cancelled) SANITIZED BRAND CFB BACTERIOSTAT
3090-205(Cancelled) SANITIZED BRAND CFC BACTERIOSTAT
3090-165(Active) SANITIZED BRAND DPN-10
3090-171(Cancelled) SANITIZED BRAND HYGIENIC SPRAY S-1 (.02)
3090-168(Active) SANITIZED BRAND HYGIENIC SPRAY S-1 FOR
INDUSTRIAL USE ONLY (.05)
3090-210(Cancelled) SANITIZED BRAND L-50
3090-200(Cancelled) SANITIZED BRAND LC BACTERIOSTAT
3090-209(Cancelled) SANITIZED BRAND PLA
3090-215(Active) SANITIZED BRAND PLA
3090-204(Cancelled) SANITIZED BRAND SOLV
3090-201(Cancelled) SANITIZED BRAND SYG BACTERIOSTAT
3090-180(Cancelled) SANITIZED BRAND SYN ANTIBACTERIAL FOR
INDUSTRIAL USE
3090-177(Active) SANITIZED BRAND XBH BACTERIOSTATIC CHEMICALS
3090-178(Active) SANITIZED BRAND XTX BACTERIOSTATIC CHEMICAL
475-165(Cancelled) SHINE & SHIELD
64931-2(Cancelled) SOF-T SEPTIC WITH BACTERIOSTAT POWERED
TEXTILE SOFTNER
1677-162(Cancelled) SOUR-STAT
67303-3() SOUR-STAT
10466-19(Cancelled) STERI-SEPTIC 300 DD ANIONIC
10466-22(Cancelled) STERI-SEPTIC UDD ANIONIC
1677-108(Cancelled) SUPER SOFT-STAT
6142-18() SUPER SOFT-STAT
4001-3(Active) TRICLOSAN
10466-27(Active) ULTRA FRESH NM
10466-20(Cancelled) ULTRA FRESH U DD CATIONIC
10466-23(Cancelled) ULTRAFRESH 300 DD CATIONIC
10466-24(Active) ULTRAFRESH 300 DD NONIONIC
10466-21(Active) ULTRAFRESH U DD NONIONIC
6390-25(Active) VIKOL THP
2829-139(Active) VINYZENE DP 7000
475-189(Cancelled) WASH TO WASH
475-188(Cancelled) WASH'N GUARD
4822-429(Active) WASTE MINDERS WITH STANGARD/4
7101-3() WASTE MINDERS WITH STANGARD/4
875-92(Cancelled) WYANDOTTE ISSUE PLUS BACTERIOSTATIC FABRIC
SOFTENER
Triclosan
[3380-34-5]
Synonyms: 2,4,4'-Trichloro-2'-hydroxydiphenyl ether; CH 3635; Irgasan
Ch 3635; Irgasan DP 300; Ster-Zac;
5-Chloro-2-(2,4-dichlorophenoxy)phenol;
2,4,4-Trichloro-2-hydroxydiphenyl ether; CH-3565;
Chloro-2-(2,4-dichlorophenoxy)phenol; Lexol 300;
Trichloro-2'-hydroxydiphenyl ether
C12H7O2Cl3
289.55
Biodegradation and Bioaccumulation. Data of
Existing Chemicals based on the CSCL, Japan
(MITI)
E1a 2,4,4-trichloro-2-..
CR No: 9-381
Cas: 3380-34-5
Chemical: 2,4,4-trichloro-2-..
Log Pow: 4.76
Aq tox LC50 48 h mg/l: 2.04
Ready biodegradability: 0.00
Bioacc highest BCF: 90.00
Query Results for 003380-34-5
Experimental log P
Chem Name:
Phenol, 5-CL-2-(2,4-dichlorophenoxy)-
Mol formula:
C12H7CL3O2
Log P:
4.76
Reference:
Chem Inspect Test Inst (1992)
Atmospheric Oxidation
Hydroxyl radical:
-----
Ozone:
-----
Nitrate radical:
-----
Ozone Depletion Potential (ODP) and Global Warming Potential
(GWP)
GWP:
-----
ODP:
-----
GWP Ref:
-----
ODP Ref:
-----
Key for GWP values: The reference compound for the GWP is indicated by
a"*".For example, those relative to CFC11 are indicated as "*CFC11."For
GWPs relative to carbon dioxide, the time horizon isindicated in
parenthesis.
Persistent Bioaccumulators (USA)
A1g :Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-
Cas: 3380-34-5
Casn: 3380345.00
Name: Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-
Molw: 290.50
Log p: 5.80
Bcf: 4.20
PC Code: 054901
CAS REG. NO. 3380-34-5
Synonym(s):
TRICHLORO-2'-HYDROXYDIPHENYL ETHER
PHENOL, 5-CHLORO-2-(2,4-DICHLOROPHENOXY)-
Trade Name(s):
TRICLOSAN
IRGASAN DP-300
LEXOL 300
CH-3565
Scientific Name(s):
CHLORO-2-(2,4-DICHLOROPHENOXY)PHENOL
CAS Numbers
CAS REG. NO. 3380-34-5
0003380345