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Re: triclosan
Hi, again,
Now that I've got my mailer straight again...
Yes, triclosan has been around for quite some time,
and I have been ranting and raving about it for quite
some time. It's in everything: deodorant, soaps,
dishwashing
liquids, anywhere where the word "deodorant
"
or disinfectant appears. It's bad news. I would tell
people "I don't like putting PCBs under my arms,
thanks".
Look in http://www.cqs.com/dioxin.htm for the list of
products
that I've found so far that should be avoided to
prevent
dioxin exposure. There are probably more.
Darn, I've given away the quiz answer. When you read
dioxin.htm,
you'll figure out why the EPA can't release the 1994
Reassessment.
Oh, well...
Jon
----
From: Tony Tweedale <ttweed@wildrockies.org>
To: Multiple recipients of list <dioxin-l@essential.org
>
Date: Thursday, July 31, 1997 12:14 PM
Subject: triclosan
many of you have seen consumer product labels w/ the
product 'triclosan' as
a disinfectant or antimicrobial (especially now that
epa has laxened its
allowe-without-having-to-register-as-a-pesticide
pesticidal claims policy).
i had been assuming it may be a chlorophenol,
contaminated w/ dioxins et
al., because of the name & because it many past (and
current?) consumer
products, incl. toothpaste & mouthwasah & soaps,
contain chlorophenols.
there was recently some mass media reporting of a
newly fda aproved colgate
toothpaste, with triclosan, that fights gingivitis &
plaque. i finally
overcame my inertia, and after several tries learned
from fda the c.a.s.
no. what follows is the various files i was able to
download from the web
using the cas # (no tox. factsheets--i didn't check
the pesticide tox
factsheet sites, and the ntp's site (the best, least
biased ones) was
down).
shock & horror, i saw triclosan (which is a chloropheno
l after all) has the
following structure (pardon the crummy representation):
OH Cl
\/\ _O_ /\/
| | | |
Cl/ \ / \/ \Cl
yet again, all but a dioxin, thus likely to be heavily
contaminated w/ same...
note one of its synnonyms, containing "2,4-dichlorophen
oxy", tho i can't
quite see the familiar, one ring, 2,4-dichlorophenoxy
herbicide
structure...
anyone w/ something to add about the prevalence of
such compounds in
consumer products we ingest or apoply to skin, about
levels of pcdd/f/hcb
etc contamination, past or present, please post to the
list. i for one
would love to learn more, and i never cease to be
stunned by the toxins we
allow in our consumer products. it's as if we were
back in the 1940's and
'50's...
---------
Triclosan (Irgasan DP 300)
Formula
MI Number
CAS Number
C.I.Number
C12H7Cl3O2
9573
3380-34-5
MI: Merck Index Number
CAS: Chemical Abstract Service Registry Number
C.I.: Chemical Index Number
Background
Triclosan (Irgasan DP 300) is a diphenyl ether used as
a preservative and
disinfectant. Irgasan DP 300 incorporated into such
footwear as men's
hosiery and insoles of shoes are called "odor-eaters"
because it is claimed
that this chemical can suppress the odor produced by
foot organism.
Synonyms
2,4,4'-Trichloro-2'-hydroxydiphenyl ether
5-Chloro-2-(2,4-dichlorophenoxy) phenol
CH 3635
Irgasan Ch 3635
Irgasan DP 300
Ster-Zac
Triclosan
Uses
Anti-odor insoles and hose
Bath additives
Commercial laundry products
Cosmetics
Deodorant soaps
Deodorants and antiperspirants
Detergents
Disposable paper products
Foot powders and sprays
Laundry products
Shampoos
Textile treatment
Cross-Reactions
Unusual Reactions
References
1. Maurer, T., et al., Predictive evaluation in
animals of the contact
allergenic potential of medically important substances.
II. Comparison of
different methods of cutaneous sensitization with
"weak" allergens.
Contact Dermatitis, 1979. 5(1): p. 1-10.
2. Veronesi, S., et al., Contact dermatitis to
triclosan. Contact Dermatitis,
1986. 15(4): p. 257-8.
3. Zaugg, T. and T. Hunziker, Germall II and triclosan
[letter]. Contact
Dermatitis, 1987. 17(4): p. 262.
4. Steinkjer, B. and L.R. Braathen, Contact dermatitis
from triclosan
(Irgasan DP 300). Contact Dermatitis, 1988. 18(4): p.
243-4.
5. Perrenoud, D., et al., Frequency of sensitization
to 13 common
preservatives in Switzerland. Swiss Contact Dermatitis
Research Group.
Contact Dermatitis, 1994. 30(5): p. 276-9.
[this one's from calif's pesticide regulation branch,
i clicked for the
company reports, but they never showed up]
Output Reporting
Query Parameters
PC Code(s): 054901
79 labels match.
Select a sort method
Scroll down and put a check by all the products you
would like more details
on.
Then press the Report button:
1624-108() 20 MULE POWER BATHROOM CLEANER
1624-109() 20 MULE POWER BATHROOM CLEANER
1624-110() 20 MULE POWER BATHROOM CLEANER
57125-8(Active) 20 MULE POWER BATHROOM CLEANER
57125-7(Active) 20 MULE POWER SPRAY BATHROOM
CLEANER
6718-19(Cancelled) AMWAY DETER SHOE AND SOCK
SPRAY
1913-23(Cancelled) AUTOMATIC VANISH TOILET BOWL
CLEANER
42964-9(Active) BAC - TEX
100-491(Cancelled) BACTERIOSTAT CH 3565
8238-4(Cancelled) BARRIER DET BACTERIOSTAT
SUPER CONC FED SPEC
P=001397 (GSA-FSS)
7048-11(Active) BIO-MAGIC RINSE G
7048-9(Cancelled) BIO-MAGIC RINSE G LIQUID
7048-10(Cancelled) BIO-MAGIC RINSE G-100
70648-1(Active) BIOKRYL I
475-187(Cancelled) BLUE AUTO SANIFLUSH TOILET
CLEANER &
DEODORIZER FORMULA A
475-178(Cancelled) BLUE SOLID SANI FLUSH TOILET
CLEANER AND
DEODORIZER
57125-6(Active) BORAXO DISINFECTANT TILE,
PORCELAIN, &
FIBERGLASS CLEANER
3573-33(Cancelled) CONCLUDE G POWERED
BACTERIOSTATIC FABRIC
SOFTNER
8238-5(Cancelled) CONQUEST DETERGENT-BACTERIOSTA
T SUPER
CONCENTRATE FED. SPEC. P-D-00139
8238-7(Cancelled) DETER-BACTERIOSTAT #306 SUPER
CONC- FEDERAL
SPEC P-D001397 GSA-FSS
8238-6(Cancelled) DETERGENT-BACTERIOSTAT #304
SUPER CONC FED
P-D 001397 (GSA-FSS)
70413-1(Active) GERM-STAT 1
100-502(Active) IRGASAN DP 300
875-110(Active) ISSUE PLUS II
1677-37(Cancelled) LAUNDRI SOFT
1677-110(Cancelled) LEMON SOFT PLUS
6142-20() LEMON SOFT PLUS
42182-1(Active) MICROBAN PLASTIC ADDITIVE "B"
9647-17(Cancelled) MYCO 30 DUST MOP
9647-16(Cancelled) MYCO S-45 BACTERIOSTATIC
DUST CONTROL AGENT
475-171(Cancelled) NEW SANI-FLUSH TOILET
CLEANER & DEODORIZER
11525-7(Cancelled) P/P DISINFECTANT CLEANER NO.
1
499-338(Cancelled) P/P OUTDOOR LOTION
499-340(Cancelled) P/P OUTDOOR LOTION
11525-12() P/P OUTDOOR LOTION
11525-22() P/P OUTDOOR LOTION
335-214(Cancelled) PENBRITE-S
1677-161(Cancelled) PENNSTAT
67303-2() PENNSTAT
1677-160(Cancelled) POWDERED PENNSOFT G
BACTERIOSTATIC FABRIC
CONDITIONER/LEXOL 300
67303-1() POWDERED PENNSOFT G BACTERIOSTATIC
FABRIC
CONDITIONER/LEXOL 300
3090-170(Cancelled) SANITIZED BRAND BACTERIOSTAT
IC ADDITIVE
WWD-2
3090-174(Cancelled) SANITIZED BRAND BACTERIOSTAT
IC CHEMICALS
SLC FOR INDUSTRIAL USE ONLY
3090-173(Cancelled) SANITIZED BRAND BACTERIOSTAT
IC FABRIC
SOFTENER
3090-199(Cancelled) SANITIZED BRAND CFB
BACTERIOSTAT
3090-205(Cancelled) SANITIZED BRAND CFC
BACTERIOSTAT
3090-165(Active) SANITIZED BRAND DPN-10
3090-171(Cancelled) SANITIZED BRAND HYGIENIC
SPRAY S-1 (.02)
3090-168(Active) SANITIZED BRAND HYGIENIC SPRAY
S-1 FOR
INDUSTRIAL USE ONLY (.05)
3090-210(Cancelled) SANITIZED BRAND L-50
3090-200(Cancelled) SANITIZED BRAND LC
BACTERIOSTAT
3090-209(Cancelled) SANITIZED BRAND PLA
3090-215(Active) SANITIZED BRAND PLA
3090-204(Cancelled) SANITIZED BRAND SOLV
3090-201(Cancelled) SANITIZED BRAND SYG
BACTERIOSTAT
3090-180(Cancelled) SANITIZED BRAND SYN
ANTIBACTERIAL FOR
INDUSTRIAL USE
3090-177(Active) SANITIZED BRAND XBH BACTERIOSTA
TIC CHEMICALS
3090-178(Active) SANITIZED BRAND XTX BACTERIOSTA
TIC CHEMICAL
475-165(Cancelled) SHINE & SHIELD
64931-2(Cancelled) SOF-T SEPTIC WITH BACTERIOSTA
T POWERED
TEXTILE SOFTNER
1677-162(Cancelled) SOUR-STAT
67303-3() SOUR-STAT
10466-19(Cancelled) STERI-SEPTIC 300 DD
ANIONIC
10466-22(Cancelled) STERI-SEPTIC UDD ANIONIC
1677-108(Cancelled) SUPER SOFT-STAT
6142-18() SUPER SOFT-STAT
4001-3(Active) TRICLOSAN
10466-27(Active) ULTRA FRESH NM
10466-20(Cancelled) ULTRA FRESH U DD CATIONIC
10466-23(Cancelled) ULTRAFRESH 300 DD CATIONIC
10466-24(Active) ULTRAFRESH 300 DD NONIONIC
10466-21(Active) ULTRAFRESH U DD NONIONIC
6390-25(Active) VIKOL THP
2829-139(Active) VINYZENE DP 7000
475-189(Cancelled) WASH TO WASH
475-188(Cancelled) WASH'N GUARD
4822-429(Active) WASTE MINDERS WITH STANGARD/4
7101-3() WASTE MINDERS WITH STANGARD/4
875-92(Cancelled) WYANDOTTE ISSUE PLUS
BACTERIOSTATIC FABRIC
SOFTENER
Triclosan
[3380-34-5]
Synonyms: 2,4,4'-Trichloro-2'-hydroxydiphenyl ether;
CH 3635; Irgasan
Ch 3635; Irgasan DP 300; Ster-Zac;
5-Chloro-2-(2,4-dichlorophenoxy)phenol;
2,4,4-Trichloro-2-hydroxydiphenyl ether; CH-3565;
Chloro-2-(2,4-dichlorophenoxy)phenol; Lexol 300;
Trichloro-2'-hydroxydiphenyl ether
C12H7O2Cl3
289.55
Biodegradation and Bioaccumulation. Data of
Existing Chemicals based on the CSCL, Japan
(MITI)
E1a 2,4,4-trichloro-2-..
CR No: 9-381
Cas: 3380-34-5
Chemical: 2,4,4-trichloro-2-..
Log Pow: 4.76
Aq tox LC50 48 h mg/l: 2.04
Ready biodegradability: 0.00
Bioacc highest BCF: 90.00
Query Results for 003380-34-5
Experimental log P
Chem Name:
Phenol, 5-CL-2-(2,4
-dichlorophenoxy)-
Mol formula:
C12H7CL3O2
Log P:
4.76
Reference:
Chem Inspect Test
Inst (1992)
Atmospheric Oxidation
Hydroxyl radical:
-----
Ozone:
-----
Nitrate radical:
-----
Ozone Depletion Potential (ODP) and Global Warming
Potential
(GWP)
GWP:
-----
ODP:
-----
GWP Ref:
-----
ODP Ref:
-----
Key for GWP values: The reference compound for the GWP
is indicated by
a"*".For example, those relative to CFC11 are
indicated as "*CFC11."For
GWPs relative to carbon dioxide, the time horizon
isindicated in
parenthesis.
Persistent Bioaccumulators (USA)
A1g :Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-
Cas: 3380-34-5
Casn: 3380345.00
Name: Phenol, 5-chloro-2-(2,4-dichlorophe
noxy)-
Molw: 290.50
Log p: 5.80
Bcf: 4.20
PC Code: 054901
CAS REG. NO. 3380-34-5
Synonym(s):
TRICHLORO-2'-HYDROXYDIPHENYL
ETHER
PHENOL, 5-CHLORO-2-(2,4-DICH
LOROPHENOXY)-
Trade Name(s):
TRICLOSAN
IRGASAN DP-300
LEXOL 300
CH-3565
Scientific Name(s):
CHLORO-2-(2,4-DICHLOROPHENOX
Y)PHENOL
CAS Numbers
CAS REG. NO. 3380-34-5
0003380345