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dioxin affects Ach receptor?
Jon & to whom it may concern
It's the actual SA article I kept from my student days (Feb 1986 Vol.254
Nr2
p.21: Dioxin by Fred H. Tschirley). Does dioxin interfere with the
acetylcholinereceptor ? Since 5-OH tryptamine (serotonin) is formed
after
hydroxylation and decarboxylation of tryptophan, does dioxin interfere
with
tryptophan dioxygenase (pyrrolase) which opens the indole ring? Patients
with
carcinoid, a tumor of the argentaffin cells of the pancreas, secrete
large
amounts of serotonin (P.N.Campbell in Biochemistry Illustrated). Let's
keep each
other updated!
Guido De Mey