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draft atsdr tox profiles, dioxins & Hg
2 separate notices of availability concerning var. dioxins &
chklorophenols, inter alia. in the 1st, note the comment on the continuing
controversy , now between epa & atsdr, on what to report as the toxicity of
Hg (Hg often used in the production of Cl2, and as a slimicide in natural
organic material such as pulp.
"Midland, Michigan [Across the USA]." USA Today, 23 October 97,
7A.
Local environmental groups will challenge the state of
Michigan's decision to allow Dow Chemical to dump
dioxin-tainted wastes into the Tittabawasse River.
White, R.F., R.G. Feldman, I.I. Eviator, et. al.,
"Hazardous Waste and Neurobehavioral Effects: A
Developmental Perspective," Environmental Research 73
Numbers 1/2(1997): 113.
The article discusses the results of three clinical
case studies of individuals who were exposed to
trichloroethylene (TCE) and other solvents. The
exposure occurred via contamination of drinking water
from hazardous waste site effluents. The three
groups were given a variety of clinical tests and the
neurobehavioral effects observed are discussed. The
findings suggest that relatively low-level
environmental exposure to solvents can be associated
with significant neurobehavioral effects.
Additionally, exposure to these solvents seems to
adversely affect the central nervous system. The
findings also suggest that the younger a person is
when exposed, the greater the range is of
neuropsychological effects observed.
---
[Federal Register: October 28, 1997 (Volume 62, Number 208)]
[Notices]
[Page 55816-55817]
>From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr28oc97-75]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Agency for Toxic Substances and Disease Registry
[ATSDR-128]
Availability of Draft Toxicological Profiles
AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR),
Department of Health and Human Services (HHS).
ACTION: Notice of availability.
-----------------------------------------------------------------------
SUMMARY: The Comprehensive Environmental Response, Compensation, and
Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments
and Reauthorization Act of 1986 (SARA) (42 U.S.C. 9604(i)(3)) directs
the Administrator of ATSDR to prepare toxicological profiles of
priority hazardous substances and to revise and publish each updated
toxicological profile as necessary. This notice announces the
availability of ten updated drafts and three new draft toxicological
profiles, comprising the 11th set, prepared by ATSDR for review and
comment.
DATES: To ensure consideration, comments on these draft toxicological
profiles must be received on or before February 17, 1998. Comments
received after the close of the public comment period will be
considered at the discretion of ATSDR based upon what is deemed to be
in the best interest of the general public.
ADDRESSES: Requests for copies of the draft toxicological profiles or
comments regarding the draft toxicological profiles should be sent to
the attention of Ms. Loretta Norman, Division of Toxicology, Agency for
Toxic Substances and Disease Registry, Mailstop E-29, 1600 Clifton
Road, NE., Atlanta, Georgia 30333.
Requests for the draft toxicological profiles must be in writing,
and must specifically identify the hazardous substance(s) profile(s)
that you wish to receive. ATSDR reserves the right to provide only one
copy of each profile requested, free of charge. In case of extended
distribution delays, requestors will be notified.
Written comments and other data submitted in response to this
notice and the draft toxicological profiles should bear the docket
control number ATSDR-128. Send one copy of all comments and three
copies of all supporting documents to the Division of Toxicology at the
above address by the end of the comment period. Because all public
comments regarding ATSDR toxicological profiles are available for
public inspection after the profile is published in final, no
confidential business information should be submitted in response to
this notice.
FOR FURTHER INFORMATION CONTACT: Ms. Loretta Norman, Division of
Toxicology, Agency for Toxic Substances and Disease Registry, Mailstop
E-29, 1600 Clifton Road, NE., Atlanta, Georgia 30333, telephone (404)
639-6322.
SUPPLEMENTARY INFORMATION: The Superfund Amendments and Reauthorization
Act (SARA) (Pub. L. 99-499) amends the Comprehensive Environmental
Response, Compensation, and Liability Act (CERCLA or Superfund) (42
U.S.C. 9601 et seq.) by establishing certain responsibilities for the
ATSDR and the Environmental Protection Agency (EPA) with regard to
hazardous substances which are most commonly found at facilities on the
CERCLA National Priorities List (NPL). Among these statutory provisions
is that the Administrator of ATSDR prepare toxicological profiles for
substances included on the priority lists of hazardous substances.
These lists identified 275 hazardous substances that ATSDR and EPA
determined pose the most significant potential threat to human health.
The availability of the revised priority list of 275 hazardous
substances was announced in the Federal Register on April 29, 1996 (61
FR 18744 ). For prior versions of the list of substances see Federal
Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988
(53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR
42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801);
and February 28, 1994 (59 FR 9486). CERCLA also requires ATSDR to
assure the initiation of a research program to fill data needs
associated with the substances.
Section 104(i)(3) of CERCLA (42 U.S.C. 9604(i)(3)) outlines the
content of
[[Page 55817]]
these profiles. Each profile will include an examination, summary and
interpretation of available toxicological information and epidemiologic
evaluations. This information and these data are to be used to
ascertain the levels of significant human exposure for the substance
and the associated health effects. The profiles must also include a
determination of whether adequate information on the health effects of
each substance is available or in the process of development. When
adequate information is not available, ATSDR, in cooperation with the
National Toxicology Program (NTP), is required to assure the initiation
of research to determine these health effects.
Although key studies for each of the substances were considered
during the profile development process, this Federal Register notice
seeks to solicit any additional studies, particularly unpublished data
and ongoing studies, which will be evaluated for possible addition to
the profiles now or in the future.
The following draft toxicological profiles will be made available
to the public on or about October 17, 1997.
------------------------------------------------------------------------
Document Hazardous substance CAS No.
------------------------------------------------------------------------
1......................... ALUMINUM...................... 007429-90-5
ALUMINUM CHLORIDE............. 007446-70-0
ALUMINUM CHLOROHYDRATE........ 001327-41-9
............................ 11097-68-0
............................ 4861-98-3
ALUMINUM LACTATE.............. 18917-91-4
ALUMINUM HYDROXIDE............ 021645-51-2
ALUMINUM OXIDE................ 001344-28-1
ALUMINUM NITRATE.............. 13473-90-0
ALUMINUM PHOSPHATE............ 007784-30-7
ALUMINUM PHOSPHIDE............ 020859-73-8
ALUMINUM FLUORIDE............. 007784-18-1
ALUMINUM SULFATE.............. 010043-01-3
2......................... CHLOROETHANE.................. 000075-00-3
3......................... CHLOROMETHANE................. 000074-87-3
4......................... 1,2-DICHLOROBENZENE........... 000095-50-1
1,3-DICHLOROBENZENE........... 000541-73-1
1,4-DICHLOROBENZENE........... 000106-46-7
CHLOROBENZENE................. 000108-90-7
DICHLOROBENZENE 025321-22-6...
5......................... 3,3,-DICHLOROBENZIDINE........ 00091-94-1
6......................... 2,4-DINITROTOLUENE............ 000121-14-2
2,6-DINITROTOLUENE............ 000606-20-2
7......................... ETHYL BENZENE................. 000100-41-4
8......................... HEXANE........................ 000110-54-3
9......................... LEAD.......................... 007439-02-1
10........................ MERCURY....................... 007439-97-6
MERCURIC (II) ACETATE......... 001600-27-7
MERCURIC (II) SULFIDE......... 001134-48-5
MERCURIC (I) CHLORIDE......... 010112-91-1
METHYLMERCURIC CHLORIDE....... 000115-09-3
PHENYLMERCURIC ACETATE........ 000062-38-4
11........................ PHENOL........................ 000108-95-2
12........................ SULFURIC ACID................. 007664-93-9
SULFUR TRIOXIDE............... 007446-11-9
13........................ SULFUR DIOXIDE................ 007446-09-5
------------------------------------------------------------------------
In regards to the draft Toxicological Profile for Mercury, it
should be noted that the EPA is currently in the process of developing
a comprehensive assessment of the potential adverse effects of mercury
emissions on human health and wildlife. In addition, ATSDR is also
aware of a number of other ongoing studies which are investigating the
potential for human health effects from mercury exposure. Because of
these special circumstances, ATSDR will monitor these efforts very
closely during the public comment period; any meaningful and compelling
information from these efforts will be critically evaluated for
incorporation into the final Toxicological Profile for Mercury, as
appropriate.
All profiles issued as ``Drafts for Public Comment'' represent
ATSDR's best efforts to provide important toxicological information on
priority hazardous substances. We are seeking public comments and
additional information which may be used to supplement these profiles.
ATSDR remains committed to providing a public comment period for these
documents as a means to best serve public health and our clients.
Dated: October 22, 1997.
Georgi Jones,
Director, Office of Policy and External Affairs, Agency for Toxic
Substances and Disease Registry.
[FR Doc. 97-28474 Filed 10-27-97; 8:45 am]
BILLING CODE 4163-70-P
------------------------------
[Federal Register: October 28, 1997 (Volume 62, Number 208)]
[Notices]
[Page 55818-55819]
>From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr28oc97-77]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Agency for Toxic Substances and Disease Registry
[ATSDR-127]
Availability of Draft Toxicological Profiles
AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR),
Department of Health and Human Services (HHS).
ACTION: Notice of availability.
-----------------------------------------------------------------------
SUMMARY: The Comprehensive Environmental Response, Compensation, and
Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments
and Reauthorization Act of 1986 (SARA) (42 U.S.C. 9604(i)(3)) directs
the Administrator of ATSDR to prepare toxicological profiles of
priority hazardous substances and to revise and publish each updated
toxicological profile as necessary. This notice announces the
availability of five updated drafts and three new draft toxicological
profiles, comprising the 10th set of profiles, prepared by ATSDR for
review and comment.
DATES: To ensure consideration, comments on these draft toxicological
profiles must be received on or before February 17, 1998. Comments
received after the close of the public comment period will be
considered at the discretion of ATSDR based upon what is deemed to be
in the best interest of the general public.
ADDRESSES: Requests for copies of the draft toxicological profiles or
comments regarding the draft toxicological profiles should be sent to
the attention of Ms. Loretta Norman, Division of Toxicology, Agency for
Toxic Substances and Disease Registry, Mailstop E-29, 1600 Clifton
Road, NE., Atlanta, Georgia 30333.
Requests for the draft toxicological profiles must be in writing,
and must specifically identify the hazardous substance(s) profile(s)
that you wish to receive. ATSDR reserves the right to provide only one
copy of each profile requested, free of charge. In case of extended
distribution delays, requestors will be notified.
Written comments and other data submitted in response to this
notice and the draft toxicological profiles should bear the docket
control number ATSDR-127. Send one copy of all comments and three
copies of all supporting documents to the Division of Toxicology at the
above address by the end of the comment period. Because all public
comments regarding ATSDR toxicological profiles are available for
public inspection after the profile is published in final, no
confidential business information should be submitted in response to
this notice.
FOR FURTHER INFORMATION CONTACT: Ms. Loretta Norman, Division of
Toxicology, Agency for Toxic Substances and Disease Registry, Mailstop
E-29, 1600 Clifton Road, NE., Atlanta, Georgia 30333, telephone (404)
639-6322.
SUPPLEMENTARY INFORMATION: The Superfund Amendments and Reauthorization
Act (SARA) (Pub. L. 99-499) amends the Comprehensive Environmental
Response, Compensation, and Liability Act (CERCLA or Superfund) (42
U.S.C. 9601 et seq.) by establishing certain responsibilities for the
ATSDR and the Environmental Protection Agency (EPA) with regard to
hazardous substances which are most commonly found at facilities on the
CERCLA National Priorities List (NPL). Among these statutory provisions
is that the Administrator of ATSDR prepare toxicological profiles for
substances included on the priority lists of hazardous substances.
These lists identified 275 hazardous substances that ATSDR and EPA
determined pose the most significant potential threat to human health.
The availability of the revised priority list of 275 hazardous
substances was announced in the Federal Register on April 29, 1996 (61
FR 18744 ). For prior versions of the list of substances see Federal
Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988
(53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR
42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801);
and February 28, 1994 (59 FR 9486). CERCLA also requires ATSDR to
assure the initiation of a research program to fill data needs
associated with the substances.
Section 104(i)(3) of CERCLA (42 U.S.C. 9604(i)(3)) outlines the
content of these profiles. Each profile will include an examination,
summary and
[[Page 55819]]
interpretation of available toxicological information and epidemiologic
evaluations. This information and these data are to be used to
ascertain the levels of significant human exposure for the substance
and the associated health effects. The profiles must also include a
determination of whether adequate information on the health effects of
each substance is available or in the process of development. When
adequate information is not available, ATSDR, in cooperation with the
National Toxicology Program (NTP), is required to assure the initiation
of research to determine these health effects.
Although key studies for each of the substances were considered
during the profile development process, this Federal Register notice
seeks to solicit any additional studies, particularly unpublished data
and ongoing studies, which will be evaluated for possible addition to
the profiles now or in the future.
The following draft toxicological profiles will be made available
to the public on or about October 17, 1997.
------------------------------------------------------------------------
Document Hazardous substance CAS No.
------------------------------------------------------------------------
1......................... CADMIUM....................... 007440-43-9
CADMIUM CARBONATE............. 000513-78-0
CADMIUM CHLORIDE.............. 010108-64-2
CADMIUM OXIDE................. 01306-19-0
CADMIUM SULFATE............... 010124-36-4
CADMIUM SULFIDE............... 01306-23-6
2......................... CHLORODIBENZO-P-DIOXIN........ 039227-53-7
DICHLORODIBENZO-P-DIOXIN...... 050585-39-2
HEPTACHLORODIBENZO-P-DIOXIN... 037871-00-4
HEXACHLORODIBENZO-P-DIOXIN.... 034465-46-8
OCTACHLORODIBENZO-P-DIOXIN.... 003268-87-9
PENTACHLORODIBENZO-P-DIOXIN... 036088-22-9
TRICHLORODIBENZO-P-DIOXIN..... 039227-58-2
TETRACHLORODIBENZO-P-DIOXIN... 041903-57-5
1,2,3,4,6,7,8- 035822-46-9
HEPTACHLORODIBENZO-P-DIOXIN.
3......................... CHLOROPHENOLS................. 000088-06-2
2,3,5,6-TETRACHLOROPHENOL..... 000935-95-5
2,4,5-TRICHLOROPHENOL......... 000095-95-4
2,4,6-TRICHLOROPHENOL......... 000088-06-2
2-CHLOROPHENOL................ 000120-83-2
4-Chlorophenol................ 000095-57-8
2,3,4,5-TETRACHLOROPHENOL..... 004901-51-3
2,3,4,6-TETRACHLOROPHENOL..... 000058-90-2
4......................... DORMALDEHYDE.................. 000050-00-0
5......................... HEXACHLOROCYCLOHEXANE......... 000608-73-1
HEXACHLOROCYCLOHEXANE, ALPHA-. 000319-84-6
HEXACHLOROCYCLOHEXANE, BETA-.. 000319-85-7
HEXACHLOROCYCLOHEXANE, DELTA-. 000319-86-8
HEXACHLOROCYCLOHEXANE, GAMMA-. 000058-89-9
6......................... HEXACHLOROCYCLOPENTADIENE..... 000077-47-4
7......................... MANGANESE..................... 007439-96-5
8......................... HYDROGEN SULFIDE.............. 007783-06-4
------------------------------------------------------------------------
All profiles issued as ``Drafts for Public Comment'' represent
ATSDR's best efforts to provide important toxicological information on
priority hazardous substances. We are seeking public comments and
additional information which may be used to supplement these profiles.
ATSDR remains committed to providing a public comment period for these
documents as a means to best serve public health and our clients.
Dated: October 22, 1997.
Georgi Jones,
Director, Office of Policy and External Affairs, Agency for Toxic
Substances and Disease Registry.
[FR Doc. 97-28476 Filed 10-27-97; 8:45 am]
BILLING CODE 4163-70-P
------------------------------