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Michigan Cancer Foundation's role in the invention of AZT, ddC and d4T
Dr. Jerome Horowitz of the Karmanos Cancer Institute (formerly known as
the Michigan Cancer Foundation) confirmed (in a telephone conversation)
that his laboratory originally synthesized the following compounds: AZT
(in 1964), ddC (in 1966) and d4T (in 1966). According to Dr. Horowitz,
ddi(Videx) is "the product of cellular degradation of ddA by adenosine
deaminase (Foreword, Anti-HIV Nucleosides: Past, Present and Future)."
The CPT page on AIDS drugs will be updated to show this new
information. Dr. Horowitz's research was helped by a grant from the
National Cancer Institute (NCI). Dr. Horowitz's lab had started
research on these class of drugs (nucleoside analogue reverse
transcriptase inhibitors) in 1961.