David, Tony, Louise; Judging Epid. Research Data

[GCJeffrey@aol.com]

David
Tony T.
Louise

Because of informal interviews with numerous
diabetes and porphyria patients and looking at
general data, I think that diabetes epidemiology
studies should include:
A1.  PCB exposure.
A2.  Dioxin exposure.
A3.  Other incinerator chemicals exposure
A4.  Exposure to other chemicals like methylene
       chloride used to decaffinate coffee.
       (See book "Chemical Exposure & Human Health"
        by Cynthia Wilson  www.ciin.org)
A5.  Exposure to "Porphyrinogenic Substances"
       (Read paper by same name by Cynthia Wilson
       www.ciin)
A5.  Exposure to biological vectors.
A6.  Exposure history of the ancestors of diabetes
       going back say 6 generations.
A7.  Extensive questionaires should be used.
A8.  Researchs often do not take hair samples or
       better tissue sample for analysis for minerals
       overall chemical exposure.
       My personal PCB-dioxin exposure lead to low
       levels of magnesium, manganese, molydeum
       and cobalt......
A8.  Inherient in the above is geographical location
      at birth and after for diabetics.
      A significant amount of diabetes occurs in the
      subtropical, tropical areas of the USA...why?
      biological vectors, chemical plants, aging 
      retirees?

Dioxin mediated/caused chronic degenerative
diseases are a multivariable problem THAT OCCUR
IN THE REAL, HIGHLY CHEMICALLY AND
BIOLOGICALLY EXPOSED WORLD.



Tony T. wrote:
[[david--on 2nd thot and after sending the below to you, I want to take the
discussion back to the list, so that people can benefit from it or
contribute or critique..  Hope you don't mind then, that I'm reposting it
to dioxin-list!]]

[[david--agree w/ what you say.  Seveso single sex/lack of exposure data
finding for diabetes is weird, but since diabetes is hormonally mediated,
it doesn't seem (quite) beyond the bounds of probability...   for VA to
approve diabetes as an Agent Orange caused illness deserving VA medical
coverage, it has to be a strong association, I imagine! (they haven't
approved many Agent Orange ilnesses).]]


DIOXIN-DIABETES

Epidemiology requires systematically
investigating:

1.  Know factors which increase the
probability that lead to the appearance
of symptoms of a chronic degenerative
disease (CDD).

2.  Know factors which increase the
probability that lead to positive tests
for a CDD per the medical professions
criteria for diagnosing; e.g. how much
excess sugar in the blood, ketones etc.

This is an interesting point with respect
to diabetes and porphyria if one considers
that these patients must be exposed to
factors like "Porphyrinogenic Substances"
and specific sugar intaked in the specific
time period before testing is done.

The Chemical Injury Information Network
(www.ciin.org) and Dr. William Morton
and others have covered this issue
extensively.

#1 and #2 may sound a bit essoteric but
contribute to the correctness of any
data collected in a research study.


3.   The political-economic factors
which may influence the reporting of
data.
Who provided the money for reseach?
Who influences Congress with campaign
money?
etc.


4.  The public preception of the CDD
and the publics willingness to report symptoms.

e.g. Diabetes, AIDS, porphyria do invoke
discrimination in employment and obtaining
medical insurance.

Diabetes is grossly undereported (100%).

Porphyria diagnoses are avoided "like the
plague" by medical professionals who:

4.1   must keep good business relations
with hospitals which have incinerators
which produce porphyria inducing dioxin
and 
4.2  avoid talk of porphyrinogenic substances
too many of which are prescription drugs.


5.  Public knowledge is often lacking for
the symptoms for a CDD which would lead
them to seek medical care.
eg. diabetes can do significant damage
and death if subtile symptoms are avoided.

Many cases of porphyria have been undetected
due to avoidance of the media to discuss those
liver spots-age spots in the context of porphyria
cutanea tarda.

Interesting that General Electric has a potential
$500 million dollar judgement against it to clean
up PCBs-dioxins from the Hudson River and GE
owns NBC television....effect on public preception?



6.   Multiple factors must be present to
manifest systems of certain chronic
degenerative diseases.


SO WHAT????

One much look at these factors when
evaluating research, not just look at
if the EPIDEMIOLOGY research data is
"statictically significant."

In light of the above, diabetes cause
epidemiology w/r should include probably
over 4,200 questions.

WHY?

It is interesting that an "emergency treatment"
for porphyria is sugar.....yet this is often
detrimental to diabetics.

I have friends diagnosed with both porphyria
and diabetes.......connections?

I know of families with both porphyria and
diabetes and those families live in the coastal
paper mill and "end of the sewer" river areas
between Jacksonville Florida and Charlston
South Carolina.  Many of these families eat
and have eaten significant amounts of seafood.


We have over 3,700 known "Porphyrinogenic
Substances" and any good dioxin related
questionaire should include exposure to
these chemicals and about 500 additional
questions about other chemical and biological
vector exposure and ancestrial history exposure.

This includes open questions like what other
chemicals have you been exposed to?

Note that I consider eating meat as a exposure
to dioxin, other chemicals and biological vectors.


AGAIN

ADA/JDA/NCHS factors in Diabetes should be
considered in diabetes epidemiology with respect
to increasing exposure to dioxin, other chemicals
and biological vectors. 

1. How much animal fat intake?
2  Where were these animals (cows etc.) raised?
3.  What is the source of any food that is trucked
    into the animal raising area?
4. How much fish and what type?
5.  Where did these fish live?
etc. etc.


The simplistic view to be taken is that
multivariable regressive analysis of about
4,200 factors will probable show us the
true multiple causes of dioxin related diabetes.

This would be partially facilitated by development
of an extensive questionaire.


George C. Jeffrey BS Chemical Engineering
Fellow Human Test Animal in the 100 year
Halide Chemical Experiment.
Citizens Reaction Against Pollution