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Re: Symptoms of dioxin Part 3/3
"Dr Aziz," "Indigenous Environmental
Network" and Neil Tangri
Porphyria Cutanea Tarda is a symptom
of dioxin toxicity. Other Porphyrias
such as VP and AIP have also been
noted in dioxin exposed workers such
as paper mill chemists.
Porphyria is closely associated with
P450 detox system suppression.
Cynthia Wilson's group wrote
"Chemical Exposure and Human Health"
which has symptoms of formaldehyde
toxicity which Dr. Sherry Rogers (NY)
says cannot be easily "broken down-
converted" out of the body if the P450
system is inhibited (by dioxin).
Formaldehyde
(From "Chemical Exposure and Human Health",
Cynthia Wilson, McFarland & Co. Jefferson NC and
London, 800 253-2187.)
SYMPTOMS/DAMAGE:
Eye, ear and throat irritation;
Acidosis;
Acute sense of smell;
Altered tissue proteins;
Anemia;
Antibodies formation;
Apathy;
Blindness;
Blood in urine;
Blurred vision;
Body aches;
Bronchial spasms;
Bronchitis;
Burns, nasal and throat;
Cardiac impairment, palpations, and arrhythmias;
Central nervous system depression;
Changes in higher cognitive functions ;
Chemical sensitivity;
Chest pains and tightness;
Chronic vaginitis;
Colds;
Coma;
Conjunctivitis;
Constipation;
Convulsions;
Corneal erosion;
Cough;
Death;
Depression;
Dermatitis;
Diarrhea;
Difficulty Concentrating;
Disorientation;
Dizziness;
DNA damage;
Drowsiness;
Ear aches;
Eczema;
Emotional upsets;
Ethmoid polyps;
Fatigue;
Fecal Bleeding;
Fetal asphyxiation;
Flu-like or cold like illness;
Frequent urination with pain;
Gastritis;
Gastrointestinal inflammation;
Headaches;
Hemolytic anemia;
Hoarseness;
Hyperactive airway disease;
Hyperactivity;
Hypomenstrual syndrome;
Immune system sensitization;
Impaired attention span;
Impaired capacity to focus attention;
Inability or difficulty swallowing;
Inability to recall words and names;
Inconsistent IQ profiles;
Inflammatory diseases of the reproductive organs;
Intestinal pain;
Intrinsic asthma;
Irritability;
Jaundice;
Joint pain, aches and swelling;
Kidney pain;
Laryngeal spasm;
Loss of memory;
Loss of sense of smell;
Loss of taste;
Malaise;
Menstrual and testicular pain;
Menstrual irregularities;
Metallic taste;
Muscle spasms and cramps;
Nasal congestion, Crusting and mucosa inflammation;
Nausea;
Nosebleeds;
Numbness and tingling of the forearms and finger tips;
Pale, clammy skin;
Partial laryngeal paralysis;
Pneumonia;
Post nasal drip;
Pulmonary edema;
Reduced body temperature;
Retarded speech pattern;
Ringing or tingling in the ear;
Schizophrenic-type symptoms;
Sensitivity to sound;
Shock;
Short term memory loss;
Shortness of breath;
Skin lesions;
Sneezing;
Sore throat;
Spacey feeling;
Speaking difficulty;
Sterility;
Swollen glands;
Tearing;
Thirst;
Tracheitis:
Tracheobronchitis;
Vertigo;
Vomiting blood;
Vomiting;
Wheezing;
Suspected of causing cancer (see comment from
NIOSH).
Genetic mutations;
Chromosomal damage;
Metabolized as formic acid.
Note: Will cross sensitize to formic acid. Comparison
of ciliostatic effects showed formaldehyde to the most
toxic of the aldehydes. EPA estimates that 15 people in
1 million will get cancer from lifetime exposure of 1
ppb. Neurotoxin.
Trade Names/synonyms: Quaternium-15; Metanal;
Meltyl aldehyde; Methylene oxide; Formalin; Formic
aldehyde; Formalith; Fyde; BVF; Morbicid;
Oxymethylene; Oxomethane; Lysoform;
Superlysoform; Fannoform; Ivalon.
NIOSH: Carcinogen at any exposure level;
NIOSH REL: 0.016 ppm (10 hr/day 40 hr. wk);
0.100 ppm (ceiling limit to not exceed
15 minutes);
OSHA: PEL: 0.750 ppm (8 hr/day-40
hr/wk-PP/S);
2000 ppm (exposure to not exceed 15
min);
NAS: There is no (constant) population
threshold for irritation effects;
NRC: Fewer than 20% but perhaps no more
10% of the general population may
be suspectable to formaldehyde and
may react acutely at any exposure level;
ACGIH: Suspected human carcinogen;
IDLH: 30 ppm;
CEHH Page 182;
References: 84,17,18,30,31,129,278,279,285,
88,290,297,299,300,304,305,309,
388,389,394,416,417a,421,423,426,457.
8. Berthold-Bond, A., Clean & Green, Woodstock,
NY: Cress Press, 1990.
14. Chesebrough-Ponds USA Co., product label for
Rave All in One hair spray 1992.
17. Concrete Facts, "99.99 Percent?" March 1991,
Vol.1 no.1 and/or Rachel's Hazardous Waste
News #207, "Hardardous Waste Incineration-
Part 4; Real Alternatives to Incinerations,"
November 14, 1988.
18. "Congress: HR 1066 Needed to Turn Heat Up
on Employers, Regulators, Congress Told",
Indoor Air Pollution News, Washington, DC:
Buraff, August 22, 1991.
30. Lander Co., product label for Rose Scented
Skin Cream, ca. 1992.
31. Lander Co., product label for Vitamin E
Lotion, ca. 1992.
129. "National Library of Medicine's Toxicology
Information Program, Agency for
Toxic Substances and Disease Registry,
Hazardous Substances Data Bank,
"Formaldehyde", as of January 11, 1992.
279. National Research Council, Assembly of Life
Sciences, Committee on Aldehydes, Based on
Toxicology and Environmental Health
Hazards, Formaldehydes and other
Aldehydes, Washington, DC: National
Academy Press, 1981.
285. New Jersey Department of Health, "Hazardous
Substance Fact Sheet "Formaldehyde", 1986.
288. Proctor and Gamble Co., label for Ivory Free
Conditioner, U.S. patent pending.
290. Redmond Products, product label for Aussie
Mega Shampoo with Papaya, 1986.
297. Swanson, J.R., "Formaldehyde: The
Psychological and Educational
Implications of Formaldehyde Toxicology,"
Seattle, WA: University of
Washington, College of Education, 1984.
299. Thomas, C.L., editor, Taber's Cyclopedic
Medical Dictionary, 16 th edition Philadelphia,
PA: F.A. Davis Company, 1989.
This a simple diagram of the overall effect
of dioxin:
==========================
GCJeffrey Macro View from combining
papers from various researchers.
==========================
Primary Endocrine Disrupters
e.g. Dioxin, etc. at very low levels
|
V
Porphyria and related
P450 Detox System Disruption
|
V
Build up of "Secondary Toxins"
(e.g. formaldehyde)
and more "Primary Toxins"
|
V
More Permanent Gene Damage -->Increase Secondary Toxin Build up
&Chronic Degenerative Diseases and inhibits removal of dioxin
"Cognitive Deficits"
"Behavioral Problems"
"Diabetes"
"Porphyria"
"Cancer"
"Neurological Effects"
See three of Cynthia Wilson's publications:
3,700 "Porphyrinogenic Substances"
http://biz-comm.com/CIIN/ click on Library
Scoll down to porphyria.
"Chemical Exposure and Human Health"
http://biz-comm.com/CIIN/ click on Book
Monthly "Our Toxic Times"
http://biz-comm.com/CIIN/ click on Library