Laryngeal carcinoma and estrogen receptor analysis

[ttweed@wildrockies.org (Tony Tweedale)]

Eur Arch Otorhinolaryngol 1998;255(9):457-61

Laryngeal carcinoma and estrogen receptor analysis in patients after long-term
follow-up.

Ogretmenoglu O, Ayas K

Department of Otolaryngology, Head and Neck Surgery, Hacettepe University
Medical Faculty, Ankara, Turkey.

[Medline record in process]

Limitations in determining the progress and treatment of malignant diseases
have prompted the investigation of new factors. Many molecules including
estrogen receptors have been studied in an effort to understand the biological
behavior of a tumor. To determine the effect of estrogen on laryngeal malignant
cells, we analyzed the clinical findings of patients during long-term follow-up
and compared these with the expression of estrogen receptors (ER). Fresh tissue
samples from 30 patients with laryngeal carcinomas were analyzed for ER by a
cytochemical method. Seven patients (23.3%) were found to be ER+. Advanced
stages of the disease in patients with supraglottic tumors were found to be
significantly ER-. While all patients were still alive for > or = 4 years in
the ER+ group, two patients were dead due to primary tumor in the ER- group.
Although the results of this study suggest that ER may play a role in
determining the prognosis of disease in certain cases, further studies with
larger series are needed before ER can be accepted as a prognostic marker.

PMID: 9833214, UI: 99050408

----------