querry--thyroid effects not receptor mediated?

[ttweed@wildrockies.org (Tony Tweedale)]

davis baltz's recent excellent final EDSTAC summary psoted to these lists
mentions briefly: '"From what is known, thyroid disrupting chemicals
usually act through non-receptor mediated mechanisms."   Not that I've ever
been trained in any endocrinology, but I have though of a hormone as a
biomolecule that acts through a receptor molecule.  Looking at a dictionary
definition & derivation of the word, I see hormone defined more broadly, as
an endocrine gland substance that has an effect on an organ.

Anyone care to share to the list any interesting insights on the mechanisms
or toxicol. of non-receptor hormonal action?

Tony Tweedale

Causality is a concept not subject to empirical demonstration. -David Hume
(1711-'76)