Re: "other" dioxins

[Philip Fleischer <philip@coc.powell-river.bc.ca>]

>I am seeking information of RELATIVE toxicities of the various dioxins.

A table in a review of published literature on PCDD/Fs uses
three references to summarize toxicity in terms of some
reported animal tests.  The first half or so is reproduced here:

Oral LD50 Values for Three Animal Species
(in ug/kg body weight)

Congener                   Guinea Pig      Mouse         Rat

Dioxins
  unchlorinated            -               >50,000       >1,000,000
  2,3-di                   -               -             >1,000,000
  2,7-di                   -               >2,000,000    >1,000,000
  2,8-di                   >300,000        847,000,000   >5,000,000
  1,3,7-tri                -               >15,000,000   >5,000,000
  2,3,7-tri                29,444          >3,000        >1,000,000
  1,3,7-tri                -               >15,000,000   >5,000,000
  1,2,3,4-tetra            -               -             >10,000,000
  1,3,6,8-tetra            >15,000,000     >2,987,000    >10,000,000
**2,3,7,8-tetra            0.6 - 2         114 - 284     22 - 45  **
  1,2,3,7,8-penta          3.1             337.5         -

The table goes on and covers some furans too.

The review was done in 1992.

Note that data like these report short term lethal effects on the
dosed animal.  Long term, sub lethal, or effects on the animal's
offspring are another matter.





Philip Fleischer    Philip@coc.Powell-River.BC.CA    604/483-4701